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British Consensus Guidelines on Intravenous Fluid Therapy for Adult Surgical Patients (GIFTASUP)

These guidelines were first published in 2008, in response to concern about the high incidence of postoperative sodium and water overload and evidence to suggest that preventing or treating this, by more accurate fluid therapy, would improve outcome.

They were then revised in 2011, when the authors learnt that Professor Joachim Boldt is under investigation following allegations of research fraud. Whilst remaining open minded as to whether these allegations would prove to be true or false, they felt that since the guidelines used six of his references there was a need to review them to see if any changes were needed after removing these six references.

The text and recommendations remained exactly as before and one review reference was added to replace the Boldt references removed. Removal of his references from these Guidelines therefore has had absolutely no impact on the recommendations for patient care.

Summary and Recommendations

From October 2006 the Association of Surgeons of Great Britain and Ireland, SARS, BAPEN Medical, the Intensive Care Society, the Association for Clinical Biochemistry and the Renal Association nominated core members of a steering committee who came together to establish consensus for good perioperative fluid prescribing. Concern arose from a high incidence of postoperative sodium and water overload, and evidence to suggest that preventing or treating this, by more accurate fluid therapy, would improve outcome.

The following recommendations are extracted from the complete document below. Members of the steering committee used the definitions of the Oxford Centre for Evidence-based Medicine Levels of Evidence (May 2001) accessed from http://www.cebm.net/index.aspx?o=1025 to assign levels of evidence each of which, after debate, was accepted unanimously.

Distinction is made (a) between fluid and electrolytes required for normal existence (daily maintenance) and (b) for resuscitation or replacement of abnormal losses. No intravenous infusion should be continued simply because it is a “routine” component of clinical care. Food and fluids should be provided orally or enterally and intravenous infusions discontinued as soon as possible.

Prescribers need to understand the effects of surgical and metabolic stress on the renin-angiotensin-aldosterone system and on vasopressin elaboration. They must take care to assess the patient’s sodium, chloride, potassium, and water requirements from a knowledge of the stress response and any current deficit or excess; they must take into consideration normal maintenance requirements and the expected composition of intestinal or other losses. Requirements thus calculated are to be met based on a quantitative knowledge of the sodium, chloride and potassium contents of the fluids prescribed. Prescription should not be made without such knowledge and no intravenous fluid should be regarded as intrinsically safe.

Nutrition should be assessed and cautiously maintained. The oedematous patient should be managed with particular care, in order to achieve successful negative sodium and water balance.

Recommendation 1
Because of the risk of inducing hyperchloraemic acidosis in routine practice, when crystalloid resuscitation or replacement is indicated, balanced salt solutions e.g. Ringer’s lactate/acetate or Hartmann’s solution should replace 0.9% saline, except in cases of hypochloraemia e.g. from vomiting or gastric drainage.
Evidence level 1b1-6

Recommendation 2
Solutions such as 4%/0.18% dextrose/saline and 5% dextrose are important sources of free water for maintenance, but should be used with caution as excessive amounts may cause dangerous hyponatraemia, especially in children and the elderly. These solutions are not appropriate for resuscitation or replacement therapy except in conditions of significant free water deficit e.g. diabetes insipidus.
Evidence level 1b7-10

Recommendation 3
To meet maintenance requirements, adult patients should receive sodium 50-100 mmol/day, potassium 40-80 mmol/day in 1.5-2.5 litres of water by the oral, enteral or parenteral route (or a combination of routes). Additional amounts should only be given to correct deficit or continuing losses.

Careful monitoring should be undertaken using clinical examination, fluid balance charts, and regular weighing when possible.
Evidence level 511

Preoperative fluid management

Recommendation 4
In patients without disorders of gastric emptying undergoing elective surgery clear non-particulate oral fluids should not be withheld for more than two hours prior to the induction of anaesthesia.
Evidence level 1a12-14

Recommendation 5
In the absence of disorders of gastric emptying or diabetes, preoperative administration of carbohydrate rich beverages 2-3h before induction of anaesthesia may improve patient well being and facilitate recovery from surgery. It should be considered in the routine preoperative preparation for elective surgery.
Evidence Level 2a15-19

Recommendation 6
Routine use of preoperative mechanical bowel preparation is not beneficial and may complicate intra and postoperative management of fluid and electrolyte balance. Its use should therefore be avoided whenever possible.
Evidence level 1a20-22

Recommendation 7
Where mechanical bowel preparation is used, fluid and electrolyte derangements commonly occur and should be corrected by simultaneous intravenous fluid therapy with Hartmann’s or Ringer-Lactate/acetate type solutions.
Evidence level 5

Recommendation 8
Excessive losses from gastric aspiration/vomiting should be treated preoperatively with an appropriate crystalloid solution which includes an appropriate potassium supplement. Hypochloraemia is an indication for the use of 0.9% saline, with sufficient additions of potassium and care not to produce sodium overload. Losses from diarrhoea/ileostomy/small bowel fistula/ileus/obstruction should be replaced volume for volume with Hartmann’s or Ringer-Lactate/acetate type solutions. “Saline depletion,” for example due to excessive diuretic exposure, is best managed with a balanced electrolyte solution such as Hartmann's.
Evidence level 5 Consensus for the electrolyte content of secretions (Table III) based on Geigy Scientific Tables23
Evidence level 2a for Hartmann’s versus 0.9% saline.1-6

Recommendation 9
In high risk surgical patients preoperative treatment with intravenous fluid and inotropes should be aimed at achieving predetermined goals for cardiac output and oxygen delivery as this may improve survival.
Evidence level 1b24-27

Recommendation 10
Although currently logistically difficult in many centres, preoperative or operative hypovolaemia should be diagnosed by flow-based measurements wherever possible. The clinical context should also be taken into account as this will provide an important indication of whether hypovolaemia is possible or likely. When direct flow measurements are not possible, hypovolaemia will be diagnosed clinically on the basis of pulse, peripheral perfusion and capillary refill, venous (JVP/CVP) pressure and Glasgow Coma Scale together with acid-base and lactate measurements. A low urine output can be misleading and needs to be interpreted in the context of the patient’s cardiovascular parameters above.
Diagnosis of hypovolaemia: Evidence level 1b28-35

Recommendation 11
Hypovolaemia due predominantly to blood loss should be treated with either a balanced crystalloid solution or a suitable colloid until packed red cells are available. Hypovolaemia due to severe inflammation such as infection, peritonitis, pancreatitis or burns should be treated with either a suitable colloid or a balanced crystalloid.In either clinical scenario, care must be taken to administer sufficient balanced crystalloid and colloid to normalise haemodynamic parameters and minimise overload. The ability of critically ill patients to excrete excess sodium and water is compromised, placing them at risk of severe interstitial oedema. The administration of large volumes of colloid without sufficient free water (e.g. 5% dextrose) may precipitate a hyperoncotic state.
Suitable colloid or crystalloid for hypovolaemia: Evidence level 1b36-44
Administration of sufficient water: Manufacturers recommendations45,46: Evidence level 5

Recommendation 12
When the diagnosis of hypovolaemia is in doubt and the central venous pressure is not raised, the response to a bolus infusion of 200 ml of a suitable colloid or crystalloid should be tested. The response should be assessed using the patient’s cardiac output and stroke volume measured by flow-based technology if available. Alternatively, the clinical response may be monitored by measurement/estimation of the pulse, capillary refill, CVP and blood pressure before and 15 minutes after receiving the infusion. This procedure should be repeated until there is no further increase in stroke volume and improvement in the clinical parameters.
Evidence level for flow-based measurements: 1b47
For bolus infusion: Evidence level 1b48
Volume to be given: Evidence level 5 (consensus)
For suitable colloid: Evidence level 1b36

Intra operative fluid management

Recommendation 13
In patients undergoing some forms of orthopaedic and abdominal surgery, intra- operative treatment with intravenous fluid to achieve an optimal value of stroke volume should be used where possible as this may reduce postoperative complication rates and duration of hospital stay.
Orthopaedic surgery: Evidence level 1b28,33
Abdominal surgery: Evidence level 1a30-32,34,48-50

Recommendation 14
Patients undergoing non-elective major abdominal or orthopaedic surgery should receive intravenous fluid to achieve an optimal value of stroke volume during and for the first eight hours after surgery. This may be supplemented by a low dose dopexamine infusion.
Evidence level 1b24-27,50,51

Postoperative fluid, and nutritional management

Recommendation 15
Details of fluids administered must be clearly recorded and easily accessible.
Evidence level 5

Recommendation 16
When patients leave theatre for the ward, HDU or ICU their volume status should be assessed. The volume and type of fluids given perioperatively should be reviewed and compared with fluid losses in theatre including urine and insensible losses.

Recommendation 17
In patients who are euvolaemic and haemodynamically stable a return to oral fluid administration should be achieved as soon as possible.

Recommendation 18
In patients requiring continuing i.v. maintenance fluids, these should be sodium poor and of low enough volume until the patient has returned their sodium and fluid balance over the perioperative period to zero. When this has been achieved the i.v. fluid volume and content should be those required for daily maintenance and replacement of any on-going additional losses.

Recommendation 19
The haemodynamic and fluid status of those patients who fail to excrete their perioperative sodium load, and especially whose urine sodium concentration is
<20mmol/L, should be reviewed.
Evidence levels for recommendations 16,17,18 & 19: 1b2,7,52-59

Recommendation 20
In high risk patients undergoing major abdominal surgery, postoperative treatment with intravenous fluid and low dose dopexamine should be considered, in order to achieve a predetermined value for systemic oxygen delivery, as this may reduce postoperative complication rates and duration of hospital stay.
Evidence level 1b34,51,60-62

Recommendation 21
In patients who are oedematous, hypovolaemia if present must be treated (as in Section 6g), followed by a gradual persistent negative sodium and water balance based on urine sodium concentration or excretion. Plasma potassium concentration should be monitored and where necessary potassium intake adjusted.
Evidence level 1b2,7,53-59,63

Recommendation 22
Nutritionally depleted patients need cautious refeeding orally, enterally or parenterally, with feeds supplemented in potassium, phosphate and thiamine. Generally, and particularly if oedema is present, these feeds should be reduced in water and sodium. Though refeeding syndrome is a risk, improved nutrition will help to restore normal partitioning of sodium, potassium and water between intra-and extra-cellular spaces.
Evidence level 5

Recommendation 23
Surgical patients should be nutritionally screened, and NICE guidelines for perioperative nutritional support adhered to. Care should be taken to mitigate risks of the refeeding syndrome.
Evidence level 5: (NICE guidelines)64

Fluid management in acute kidney injury (AKI)

Recommendation 24
Based on current evidence, higher molecular weight hydroxyethyl starch (hetastarch and pentastarch MW ≥ 200 kDa) should be avoided in patients with severe sepsis due to an increased risk of AKI.65-67
Evidence level 1b

Recommendation 25
Higher molecular weight hydroxyethyl starch(hetastarch and pentastarch MW ≥ 200 kDa) should be avoided in brain-dead kidney donors due to reports of osmotic- nephrosis-like lesions.66
Evidence level 2b

Recommendation 26
Balanced electrolyte solutions containing potassium can be used cautiously in patients with AKI closely monitored on HDU or ICU in preference to 0.9% saline. If free water is required 5% dextrose or dextrose saline should be used. Patients developing hyperkalaemia or progressive AKI should be switched to non potassium containing crystalloid solutions such as 0.45% saline or 4%/0.18 dextrose/saline
Ringer’s lactate versus 0.9% saline for patients with AKI1
Evidence level 1b

Recommendation 27
In patients with AKI fluid balance must be closely observed and fluid overload avoided. In patients who show signs of refractory fluid overload, renal replacement therapy should be considered early to mobilize interstitial oedema and correct extracellular electrolyte and acid base abnormalities.
Evidence level 568

Recommendation 28
Patients at risk of developing AKI secondary to rhabdomyolysis must receive aggressive fluid resuscitation with an isotonic crystalloid solution to correct hypovolaemia. There is insufficient evidence to recommend the specific composition of the crystalloid.
Evidence level 569

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